Topic: Irinotecan
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what is irinotecan?
Irinotecan is a cancer medication that interferes with the growth and spread of cancer cells in the body. Irinotecan is used to treat cancers of the colon and rectum. It is usually given with other cancer medicines in a combination chemothe... Read More »
Source: http://www.drugs.com/mtm/Camptosar.html
What is dosage of Irinotecan ?
Metastatic Colon or Rectal Cancer Adults Combination therapy Regimen 1 IV Irinotecan 125 mg/m 2 over 90 min, leucovorin 20 mg/m 2 bolus, and 5-fluorouracil 500 mg/m 2 bolus on days 1, 8, 15, and 22. The dose of leucovorin should be administ... Read More »
Source: http://www.drugs.com/ppa/irinotecan.html
What are adverse reactions of Irinotecan ?
Cardiovascular Flushing/vasodilation (11%); thromboembolic reactions (5%); hypotension (2%); bradycardia; myocardial ischemic events (postmarketing). CNS Asthenia (76%); dizziness (21%); insomnia (19%); headache (17%); somnolence (9%); conf... Read More »
Source: http://www.drugs.com/ppa/irinotecan.html
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Irinotecan
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Treatment of metastatic cancer of the colon or rectum as first-line therapy in combination with 5-fluorouracil and leucovorin or in patients whose disease has progressed or recurred after standard treatment with fluorouracil. Unlabeled Uses...
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Source: http://www.drugs.com/ppa/irinotecan.html
Pregnancy Category D . May cause fetal harm. Lactation Undetermined. Breast-feeding should be discontinued during therapy with irinotecan. Children Safety and efficacy not established. Elderly Exercise particular caution in monitoring the e...
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Source: http://www.drugs.com/ppa/irinotecan.html
Known hypersensitivity to irinotecan or any of the product excipients.
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Source: http://www.drugs.com/ppa/irinotecan.html
Your doctor may recommend a DNA test before your first dose of irinotecan. Some people are genetically more likely to have certain side effects from irinotecan. Irinotecan is injected into a vein through an IV. You will receive this injecti...
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Source: http://www.drugs.com/mtm/Camptosar.html
Individuals who are homozygous for the UGT1A1*28 allele are at increased risk for neutropenia following the initiation of irinotecan treatment. A reduced initial dose should be considered for patients known to be homozygous for the UGT1A1*2...
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Source: http://www.drugs.com/dosage/irinotecan.html
General Outside of a well-designed clinical study, Irinotecan hydrochloride injection should not be used in combination with the "Mayo Clinic" regimen of 5-FU/LV (administration for 4-5 consecutive days every 4 weeks) because of reports of ...
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Source: http://www.drugs.com/pro/irinotecan.html
