Topic: P glycoprotein
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What is P-Glycoprotein?
P-gp is a phosphorylated and glycosylated plasma membrane protein belonging to the ATP-binding cassette superfamily of transport proteins. MDR1 P-gp (referred to simply as P-gp in this article) is a transmembrane protein that is 1280 amino ... Read More »
Source: http://www.aegis.com/pubs/gmhc/2002/GM160103.html
how P-glycoprotein (ABCB1) harnesses the energy of ATP binding an...
The efflux of drugs by the multidrug transporter P-glycoprotein (Pgp; ABCB1) is one of the principal means by which cancer cells evade chemotherapy and exhibit multidrug resistance. Mechanistic studies of Pgp-mediated transport, however, tr... Read More »
Source: http://www.ncbi.nlm.nih.gov/pubmed/17237262
What is the relationship between P-glycoprotein... [Melanoma Res....
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Source: http://www.ncbi.nlm.nih.gov/pubmed/11930106
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P glycoprotein
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A number of studies have reported that increased P-glycoprotein expression in drug-resistant tumour cells may be associated with decreased expression of a family of surface glycoproteins. However, despite its potential biological and clinic...
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Source: http://www.ncbi.nlm.nih.gov/pubmed/11930106
The influence of P-glycoprotein (P-gp) on intestinal absorption of drugs was investigated by comparison of the uptakes of two P-gp substrates, verapamil and vinblastine, using intestinal segments of wild-type and mdr1a/1b gene-deficient (md...
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Source: http://www.medscape.com/medline/abstract/16858128
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Source: http://www.ncbi.nlm.nih.gov/pubmed/17237262
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Source: http://www.druglib.com/abstract/og/ogihara-t_drug-metab-pharmacok...
This year marks the 30th anniversary of the discovery of the multidrug resistance (MDR) ATP-binding cassette (ABC) transporter P-glycoprotein (P-gp). Since then a considerable research effort has attempted to provide a greater understanding...
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Source: http://www.medscape.com/medline/abstract/17208306
Elevation of P-glycoprotein levels leads to resistance to many chemotherapeutic agents by decreasing drug uptake and retention by tumor cells.
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Source: http://www.angelfire.com/sc3/toxchick/molbiocancer/molbiocancer25...
