Yes, there are prognostic and other clinical differences. Here are some highlighted: Gastric GISTs with KIT exon 11 deletions behave more aggressively than those with point mutations, but this may not be true in small intestinal GISTs. In ...
http://www.gistsupport.org/ask-the-professional/gist-pa...
Assume that protein synthesis always reads along a chromosome three bases at a time to code for each successive amino acid in a protein. There are two kinds of point mutations, a base substitution, and a base deletion. How are these two t...
http://www.brainmass.com/homework-help/biology/biology-...
p53 is the most common gene mutated in human cancer. It is mutated in over 50% of all malignant tumors. Ras is the most commonly mutated protooncogene in human cancer. It is mutated in about 25-30% of malignancies. APC mutation is seen in v...
http://pathcuric1.swmed.edu/PathDemo/neoqs/neoqs.htm
An emerging debate in evolutionary biology concerns whether certain types of mutations (e.g. mutations in cis-regulatory regions, in transcription factors, in enzyme-coding genes) are fixed preferentially during adaptive evolution. Although...
http://www.darwin200.cn/bio/Rausher_M.html
Generally the milder mutations are indicative of milder disease, but there is variability of symptoms even among patients with identical mutations.
http://www.cysticfibrosis.com/ambry.cfm
A silent mutation - it's a mutation that replaces one nucleotide with another one but doesn't change the amino acid, because some amino acids can have more than one codon that encodes to them.
http://uk.answers.yahoo.com/question/index?qid=20090308...
It has been suggested that the clinical variability is genetically determined by different mutations in the FUCA 1 gene. Several lines of evidence controvert this hypothesis. 1) Family pedigree studies show clinical variability within the s...
http://www.mannosidosis.org/fucosidosisOverview.htm