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Synonyms
ir·ri·ta·tion (ĭŕĭ-tā́shən)

noun 

    1. The act of irritating.
    2. The condition of being irritated; vexation: honked the horn with irritation at the delay.
  2. A source of irritation.
  3. Pathology A condition of inflammation, soreness, or irritability of a bodily organ or part.
  4. Physiology The elicitation of activity or response in an animal or plant organ or tissue.