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These antibodies, via antibody-dependent enhancement (ADE) of infection, are able to facilitate dengue virus (DENV) growth in Fc-bearing host cells. The mechanism of ADE-enhanced DENV production is believed to be mediated through increasing the infected-cell mass.
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Brazil is experiencing severe yearly outbreaks of dengue virus (DENV) serotypes 1 to 3 [2]. Since its brief incursion into the eastern Brazilian Amazon in ...
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DENV Internalization: This review focuses on the putative molecules and mechanisms involved in the complex process of dengue virus binding and entry into mosquito and mammalian cells in primary infections. ... Initial electron microscopy studies indicated that DENV-2 penetrated directly into the cytoplasm of human monocytes,
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 98, Issue 9, Pages 553-562, September 2004, Authors:TS De Simone; RMR Nogueira; ...
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In Latin America, >30 countries and regions have reported DENV circulation, totaling >900,000 dengue fever cases, 26,000 DHF cases, and 300 deaths in 2007 (2). Following the breakdown of a hemisphere-wide Aedes aegypti mosquito eradication campaign conducted in the mid-20th century, vector populations expanded and all...
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Cook Islands Biodiversity Database ... Dengue virus [DENV 1-4]; TAXONOMY: VIRUSES; RNA; positive ssRNA; Flaviviridae ... Enlarged Image of 'Dengue virus [DENV 1-4]'
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The chapters are balanced by contributions from established investigators who have dedicated their careers to DENV research with those from newcomers who have recently made significant contributions the study of DENV.
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The chimpanzee monoclonal antibody (MAb) 5H2 is specific for dengue virus type 4 (DENV-4) and neutralizes the virus at a high titer in vitro. The epitope detected by the antibody was mapped by sequencing neutralization escape variants of the virus. ... Lai CJ, Goncalvez AP, Men R, ... Laboratory of Infectious Diseases,
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BACKGROUND: The natural history of wild-type dengue virus (DENV) infections of humans, including incubation and infectious periods, requires further study. METHODS: Two experimental studies in the Philippines of DENV-4 (1924-1925) and DENV-1 (1929-1930) were reexamined. ... Nishiura H, Halstead SB ... Dengue Fever Books;
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Mosquito-borne flaviviruses represent a serious public health issue in Brazil, with Dengue viruses (DENV 1–4), Saint Louis Encephalitis virus (SLEV), ...
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