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Antineoplastic resistance

en.wikipedia.org/wiki/Antineoplastic_resistance

Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the ... Cancer cells can become resistant to multiple drugs by various mechanisms, .... In breast cancer, drug ...

Mechanisms of Acquired Resistance to Targeted Cancer Therapies

www.medscape.com/viewarticle/769431

Mechanisms underlying acquired resistance to pathway-targeted drugs are being pursued ... breast and ovarian cancers with PARP inhibitors, and in basal cell ...

Drug Resistance in Cancer: An Overview

www.ncbi.nlm.nih.gov/pmc/articles/PMC4190567/

Sep 5, 2014 ... However, cancer cells can also develop resistance to such ... in 30% of breast cancer patients [14], and drug resistance can result after long ...

Differential drug resistance acquisition to doxorubicin and paclitaxel ...

cancerci.biomedcentral.com/articles/10.1186/s12935-014-0142-4

To further illustrate this drug-specific effect, possible mechanisms that enable breast cancer cells MCF-7 to acquire MDR to either paclitaxel (PTX) or doxorubicin ...

Prediction of signaling cross-talks contributing to acquired drug ...

bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-014-0135-x

Drug resistance is a major obstacle in drug efficacy that causes cancer cells to .... that in breast cancer cell lines resistant to tamoxifen, a cross-talk mechanism ...

New mechanism of acquired resistance to breast cancer drugs ...

www.sciencedaily.com/releases/2015/02/150202123301.htm

Feb 2, 2015 ... After seeing that pan-ERBB inhibitors remain effective against ERBB2-positive breast cancer cells with acquired resistance to anti-ERBB2 ...

Cancer multidrug resistance : Article : Nature Biotechnology

www.nature.com/nbt/journal/v18/n10s/full/nbt1000_IT18.html

This allows tumor cells to avoid the toxic effects of the drug or molecular processes ... Isis, for example, is using its antisense technology to develop drugs to block the ... Annamycin is under development for the treatment of drug- resistant breast ...

Gene expression alterations in doxorubicin resistant MCF7 breast ...

www.sciencedirect.com/science/article/pii/S0888754312002297

In contrast, acquired resistance develops in tumors that were initially sensitive to ... cancer expresses a different array of drug-resistance genes, and even cells within ... In order to identify changes in gene expression in breast cancer cells that ...

Drug-resistant breast cancer cell line displays cancer stem cell ...

link.springer.com/article/10.1007/s13346-012-0113-z

Drug resistance Breast cancer stem cell Surface markers Epithelial ..... The acquisition of CD24<sup>−</sup>/CD44<sup>+</sup> phenotype, along with other BCSC markers, signifies ...

Study identifies first potential targeted drug for triple-negative breast ...

www.dana-farber.org/Newsroom/News-Releases/study-ids-first-potential-targeted-drug-for-triple-negative-breast-cancer-and-uncovers-drug-resistance-mechanism.aspx

Jan 6, 2016 ... Triple-negative breast cancer – named for the absence of three key receptors ... “ Knowing the resistance mechanism could not only help us develop better ... Nor had the cells acquired the ability to pump the drugs out of their ...

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Mechanisms and insights into drug resistance in cancer - NCBI

www.ncbi.nlm.nih.gov

Mar 14, 2013 ... Cancer drug resistance continues to be a major impediment in .... and mitoxantrone resistance protein [MXR; also known as breast cancer ... Many cancer cells develop an overreliance or dependency on an oncogene. This is ...

Acquisition of epithelial-mesenchymal transition phenotype in the ...

breast-cancer-research.biomedcentral.com

May 21, 2015 ... For example, tamoxifen-resistant MCF-7 breast cancer cells (MCF-7R) ... between drug resistance and the induction of EMT in cancer [10, 14]; ...

Multiple mechanisms underlying acquired resistance ... - BMC Cancer

bmccancer.biomedcentral.com

Multiple mechanisms underlying acquired resistance to taxanes in selected ... Breast cancer Taxane Doxorubicin Chemoresistance MCF-7 cell ABC proteins β- tubulin ... Resistance to chemotherapy can occur prior to drug treatment (primary or ...