Antineoplastic resistance, often used interchangeably with chemotherapy
resistance, is the ... Cancer cells can become resistant to multiple drugs by
various mechanisms, .... In breast cancer, drug ...
Mechanisms underlying acquired resistance to pathway-targeted drugs are being
pursued ... breast and ovarian cancers with PARP inhibitors, and in basal cell ...
Sep 5, 2014 ... However, cancer cells can also develop resistance to such ... in 30% of breast
cancer patients , and drug resistance can result after long ...
To further illustrate this drug-specific effect, possible mechanisms that enable
breast cancer cells MCF-7 to acquire MDR to either paclitaxel (PTX) or
Drug resistance is a major obstacle in drug efficacy that causes cancer cells to ....
that in breast cancer cell lines resistant to tamoxifen, a cross-talk mechanism ...
Feb 2, 2015 ... After seeing that pan-ERBB inhibitors remain effective against ERBB2-positive
breast cancer cells with acquired resistance to anti-ERBB2 ...
This allows tumor cells to avoid the toxic effects of the drug or molecular
processes ... Isis, for example, is using its antisense technology to develop drugs
to block the ... Annamycin is under development for the treatment of drug-
resistant breast ...
In contrast, acquired resistance develops in tumors that were initially sensitive to
... cancer expresses a different array of drug-resistance genes, and even cells
within ... In order to identify changes in gene expression in breast cancer cells
Drug resistance Breast cancer stem cell Surface markers Epithelial ..... The
acquisition of CD24<sup>−</sup>/CD44<sup>+</sup> phenotype, along with other BCSC markers,
Jan 6, 2016 ... Triple-negative breast cancer – named for the absence of three key receptors ... “
Knowing the resistance mechanism could not only help us develop better ... Nor
had the cells acquired the ability to pump the drugs out of their ...