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Antineoplastic resistance

en.wikipedia.org/wiki/Antineoplastic_resistance

Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the ... Cancer cells can become resistant to multiple drugs by various mechanisms, .... In breast cancer, drug ...

Mechanisms and insights into drug resistance in cancer - NCBI

www.ncbi.nlm.nih.gov/pmc/articles/PMC3596793/

Mar 14, 2013 ... Cancer drug resistance continues to be a major impediment in .... and mitoxantrone resistance protein [MXR; also known as breast cancer ... Many cancer cells develop an overreliance or dependency on an oncogene. This is ...

Acquisition of epithelial-mesenchymal transition phenotype in the ...

breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0579-y

May 21, 2015 ... For example, tamoxifen-resistant MCF-7 breast cancer cells (MCF-7R) ... between drug resistance and the induction of EMT in cancer [10, 14]; ...

New mechanism of acquired resistance to breast cancer drugs ...

www.sciencedaily.com/releases/2015/02/150202123301.htm

Feb 2, 2015 ... After seeing that pan-ERBB inhibitors remain effective against ERBB2-positive breast cancer cells with acquired resistance to anti-ERBB2 ...

Gene expression alterations in doxorubicin resistant MCF7 breast ...

www.sciencedirect.com/science/article/pii/S0888754312002297

In contrast, acquired resistance develops in tumors that were initially sensitive to ... cancer expresses a different array of drug-resistance genes, and even cells within ... In order to identify changes in gene expression in breast cancer cells that ...

Induction of Stable Drug Resistance in Human Breast Cancer Cells ...

journals.plos.org/plosone/article?id=10.1371/journal.pone.0021112

Herein, we utilized combinatorial ZF-TF library technology to better understand how breast cancer cells acquire resistance to fulvestrant, a clinically important ...

Mechanisms of Gefitinib-mediated reversal of tamoxifen resistance ...

www.nature.com/articles/srep07835

Feb 3, 2015 ... However, primary or acquired drug resistance is the primary cause of the ... Therefore, ER re-expression in ER-negative breast cancer cells for ...

Cytokines in cancer drug resistance: Cues to new therapeutic ...

www.sciencedirect.com/science/article/pii/S0304419X16300270

They may develop multiple mechanisms of drug resistance, including ..... This study revealed that breast cancer cells could acquire the ability to express IL-6, ...

Resistance to cancer drug found to occur naturally in the breast ...

breastcancernow.org/news-and-blogs/news/resistance-to-cancer-drug-found-to-occur-naturally-in-the-breast

Breast Cancer Now funded researchers have discovered that genetic mutations ... cells may develop resistance to MPS1 inhibitors, a new type of cancer drug ...

Study identifies first potential targeted drug for triple-negative breast ...

www.dana-farber.org/Newsroom/News-Releases/study-ids-first-potential-targeted-drug-for-triple-negative-breast-cancer-and-uncovers-drug-resistance-mechanism.aspx

Jan 6, 2016 ... Triple-negative breast cancer – named for the absence of three key receptors ... “ Knowing the resistance mechanism could not only help us develop better ... Nor had the cells acquired the ability to pump the drugs out of their ...

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Drug Resistance in Cancer: An Overview

www.ncbi.nlm.nih.gov

Sep 5, 2014 ... However, cancer cells can also develop resistance to such ... in 30% of breast cancer patients [14], and drug resistance can result after long ...

Differential drug resistance acquisition to doxorubicin and paclitaxel ...

cancerci.biomedcentral.com

To further illustrate this drug-specific effect, possible mechanisms that enable breast cancer cells MCF-7 to acquire MDR to either paclitaxel (PTX) or doxorubicin ...

Cancer multidrug resistance : Article : Nature Biotechnology

www.nature.com

This allows tumor cells to avoid the toxic effects of the drug or molecular processes ... Isis, for example, is using its antisense technology to develop drugs to block the ... Annamycin is under development for the treatment of drug- resistant breast ...