Sep 30, 2013 ... Research like the Zelboraf tests, that fine-tune treatments to the genetic profile of
patients, is fuelling a rethink over how new cancer drugs are ...
Sep 19, 2016 ... Skip to main page content ... The new policy amplifies the earlier position,
reasserting two closely ... However, intent alone does not underwrite an actual
therapeutic claim. ... drug regimens that are ultimately vindicated in randomized
trials. ... Because only one in 20 cancer drugs introduced into trials is ...
www.focr.org/sites/default/files/Immunotx final 11 4.pdf
Renzo Canetta, Vice President, Oncology Global Clinical Research, Bristol-
Myers Squibb ..... Insight: How new cancer drugs can skip randomized trials.
Oct 23, 2012 ... Skip to main content; Skip to navigation; Resources · How To · About NCBI
Accesskeys ... Keywords: cancer, personalized medicine, N-of-1, omics,
longitudinal ... (NGS) has already yielded profound new insights into cancer
biology. ... However, randomized trials can encounter difficulty in the face of ...
Skip to main content; Skip to navigation; Resources · How To · About NCBI ...
Randomized controlled trials — the gold standard for clinical drug evaluation —
can't ... For the new cancer therapies, observational cohort studies (OCSs) can
help ..... is providing important insights into current treatment practices for thi...
We can also do better by doing research on combinations of new and .....
Steenhuysen J, Hirschler B. Insight: How new cancer drugs can skip randomized
Mar 30, 2016 ... Skip Navigation ... Pragmatic Randomized Clinical Trials: A Proposal to Enhance
... of real-world data to gain further insight into the impact of new drugs as ... We
propose that for oncology drugs that demonstrate “exceptional .... but the
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Apr 11, 2016 ... FDA and Clinical Drug Trials: A Short History: article by Suzanne White Junod,
Ph.D. ... In the future, FDA could use these new tools not only to ban Banbar, but
to ... products submitted for approval to treat serious diseases (i.e. cancer ....
Although several kinds of randomized controlled trial methodologies ...
Oct 21, 2016 ... Skip to content ... Keytruda is one of a new class of immunotherapy drugs known
as ... In the KEYNOTE-045 trial, the patients were randomized to receive ...
Further details of the results will be presented at scientific meetings and
published in journals. ... Email the editors at firstname.lastname@example.org.
Jan 12, 2017 ... For the first time, we now have a randomized trial comparing active monitoring,
surgery, and radiation therapy for the management of localized ...