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Insight: How new cancer drugs can skip randomized trials | Reuters

www.reuters.com/article/us-cancer-drugs-insight-idUSBRE98P05N20130930

Sep 30, 2013 ... Research like the Zelboraf tests, that fine-tune treatments to the genetic profile of patients, is fuelling a rethink over how new cancer drugs are ...

ISSUE BRIEF - Friends of Cancer Research

www.focr.org/sites/default/files/Immunotx final 11 4.pdf

Renzo Canetta, Vice President, Oncology Global Clinical Research, Bristol- Myers Squibb ..... Insight: How new cancer drugs can skip randomized trials. 2013.

And now for something completely different: drugs that work!—The ...

cco.amegroups.com/article/view/3862/4831

We can also do better by doing research on combinations of new and ..... Steenhuysen J, Hirschler B. Insight: How new cancer drugs can skip randomized trials.

Can we deconstruct cancer, one patient at a time?

www.ncbi.nlm.nih.gov/pmc/articles/PMC4221262/

Oct 23, 2012 ... Skip to main content; Skip to navigation; Resources · How To · About NCBI Accesskeys ... Keywords: cancer, personalized medicine, N-of-1, omics, longitudinal ... (NGS) has already yielded profound new insights into cancer biology. ... However, randomized trials can encounter difficulty in the face of ...

Measures of Outcome in Metastatic Breast Cancer: Insights From a ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC4041678/

May 2, 2014 ... Skip to main content; Skip to navigation; Resources · How To · About NCBI Accesskeys ... The choice of OS as a primary endpoint for clinical trials could not be ... Although randomized clinical trials are recognized as the highest level of ... In recent years, several new drugs have been proposed for MBC, b...

Overviews on FDA History > FDA and Clinical Drug Trials: A Short ...

www.fda.gov/AboutFDA/WhatWeDo/History/Overviews/ucm304485.htm

Apr 11, 2016 ... FDA and Clinical Drug Trials: A Short History: article by Suzanne White Junod, Ph.D. ... In the future, FDA could use these new tools not only to ban Banbar, but to ... products submitted for approval to treat serious diseases (i.e. cancer .... Although several kinds of randomized controlled trial methodologies ...

Dana-Farber/Brigham and Women's Cancer Center | Cancer ...

www.brighamandwomens.org/bwhcancer/dfcibwh_cancer_treatment.aspx?id=6442451333

Gene Tests Identify Breast Cancer Patients Who Can Skip .... Dr. Ian Krop led a study identifying a new breast cancer treatment .... Dr. Harold Burstein provided insight to dispel the myth that antiperspirants cause breast cancer. .... of Medicine , that consisted of four phase 3 randomized trials in ...

FDA Approves New Therapy for Metastatic Breast CancerInsight

blog.dana-farber.org/insight/2015/02/fda-approves-new-therapy-for-metastatic-breast-cancer/

Feb 9, 2015 ... Skip to content ... New Experimental Breast Cancer Drug Shows Promise ... a trial of 165 women with ER-positive advanced breast cancer who had not ... randomized phase II study and full approval will depend on results of a ...

Immunotherapy Beats Chemotherapy for Advanced Bladder Cancer ...

blog.dana-farber.org/insight/2016/10/keytruda-immunotherapy-beats-chemotherapy-for-advanced-bladder-cancer-patients/

Oct 21, 2016 ... Skip to content ... Keytruda is one of a new class of immunotherapy drugs known as ... In the KEYNOTE-045 trial, the patients were randomized to receive ... Further details of the results will be presented at scientific meetings and published in journals. ... Email the editors at insight_blog@dfci.harvard.edu.

Research Advances - Dana-Farber Cancer Institute | Boston, MA

www.dana-farber.org/Research/Research-Advances.aspx

New drug beats standard therapy in advanced kidney cancer (November 14, 2016) ... of a randomized phase II clinical trial by researchers at Dana-Farber Cancer .... Surgery can lengthen survival of metastatic kidney cancer patients treated ..... This insight could open new avenues for preventing and treating prostate cancer.

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Clinical Trials: More Trials, Fewer Tribulations - Scientific American

www.scientificamerican.com

May 28, 2014 ... Skip to main content ... They assert that conventional randomized trials are too costly, delay the ... It is one of a number of oncology drugs to be approved for use by .... “We will need to test a new strategy of customization per patient and ... drug testing as an opportunity to gain insight into the disease rather ...

Pragmatic Randomized Clinical Trials: A Proposal to Enhance ...

annonc.oxfordjournals.org

Mar 30, 2016 ... You can change your cookie settings at any time. ... Skip Navigation ... Pragmatic Randomized Clinical Trials: A Proposal to Enhance Evaluation ... of real-world data to gain further insight into the impact of new drugs as they are ... We propose that for oncology drugs that demonstrate “exceptional activity” in .....

The Value of Observational Cohort Studies for Cancer Drugs - NCBI

www.ncbi.nlm.nih.gov

Skip to main content; Skip to navigation; Resources · How To · About NCBI ... Randomized controlled trials — the gold standard for clinical drug evaluation — can't ... For the new cancer therapies, observational cohort studies (OCSs) can help ..... is providing important insights into current treatment practices for thi...