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Tasquinimod is an Allosteric Modulator of HDAC4 Survival Signaling ...


Nov 13, 2012 ... The active vs. and inactive conformations of HDAC4 were overlaid using the Ca ... Human HIF-Regulated cDNA Plate Array from Signosis Inc (Sunnyvale .... and decreasing pH, 60% knock down of HDAC4 decreases survival of LNCaPs, ..... Kallberg E, Vogl T, Liberg D, Olsson A, Bjork P, Wilkstrom P, et al.

Patent WO2014145035A1 - Methods of making cancer compositions ...


Sep 18, 2014 ... Applicant, Genspera, Inc. ... and (d) reacting the compound of Formula 6 with the compound of ..... Sci., USA 1996;93:749- 753; Mhaka, A., et al, Cancer Biol Ther. ... by PSMA in vitro and is ~ 60-fold more toxic to PSMA expressing vs. ..... with 1.0 L of 6 M HC1 over 30 minutes (pH~3) a white slurry develops.

Full Text - Molecular Cancer Therapeutics


May 5, 2009 ... Rabbit polyclonal anti-AR (N-20), Cyclin D1 (H-295), GADD34 .... 2A), and completion of the process of cellular fragmentation into Annexin V–positive apoptotic bodies (30, 41, 42). ..... J.T. Isaacs and S.R. Denmeade: financial interest, Genspera, Inc., and ..... Singh P,; Mhaka AM,; Christensen SB,; et al.

Tasquinimod Is an Allosteric Modulator of ... - Cancer Research


Feb 15, 2013 ... Reagents. Reagents: G202 (GenSpera); Tasquinimod (Active Biotech ... Tris HCl pH 7.4 with 150 mmol/L NaCl/1% Triton and protease inhibitor ... (HUVECs; Lonza Walkersville, Inc.) with modification that. 20 mL of ... Isaacs et al. ...... Raman V, Artemov D, Pathak AP, Winnard PT, McNutt S, Yudina A, et al.

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Mhaka,Ph.D. v. Genspera, Inc. et. al. patent lawsuit - PriorSmart.com


Nov 9, 2012 ... Mhaka,Ph.D. false marking lawsuit against Genspera, Inc. et. al. in Maryland.

Engineering a Prostate-Specific Membrane Antigen–Activated ...


Jun 27, 2012 ... 1, D and E). ..... Purified G202 for animal studies was provided by GenSpera Inc. PSMA ... of Milowsky et al. with a PSMA antibody (clone 3E6; Dako) diluted 1:20 in .... The role of calcium, pH, and cell proliferation in the programmed ... Rao RV, Castro-Obregon S, Frankowski H, Schuler M, Stoka V, del Rio G ...