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Engineering a Prostate-Specific Membrane Antigen-Activated Tumor ...

content.stockpr.com/genspera/db/Publications/673/pdf/120627_SCI.pdf

Jun 27, 2012 ... Samuel R. Denmeade,1* Annastasiah M. Mhaka,1 D. Marc Rosen,1 ... George Wilding,3 Michael A. Carducci,1 Craig A. Dionne,4 Jesper V. Møller,2,5 Poul Nissen,2,6 ...... Purified G202 for animal studies was provided by GenSpera Inc. ... Milowsky et al. with a PSMA antibody (clone 3E6; Dako) diluted 1:20.

Amino acid containing thapsigargin analogues deplete androgen ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC3383025/

May 5, 2009 ... Rabbit polyclonal anti-AR (N-20), Cyclin D1 (H-295), GADD34 (S-20), .... 2A), and completion of the process of cellular fragmentation into Annexin V–positive apoptotic bodies (30, 41, 42). ..... J.T. Isaacs and S.R. Denmeade: financial interest, Genspera, Inc., and .... Singh P, Mhaka AM, Christensen SB, et al.

Patent WO2014145035A1 - Methods of making cancer compositions ...

www.google.com/patents/WO2014145035A1?cl=en

Sep 18, 2014 ... Applicant, Genspera, Inc. ... and (d) reacting the compound of Formula 6 with the compound of ..... Sci., USA 1996;93:749- 753; Mhaka, A., et al, Cancer Biol Ther. ... by PSMA in vitro and is ~ 60-fold more toxic to PSMA expressing vs. ..... with 1.0 L of 6 M HC1 over 30 minutes (pH~3) a white slurry develops.

Tasquinimod Is an Allosteric Modulator of ... - Cancer Research

cancerres.aacrjournals.org/content/early/2013/02/06/0008-5472.CAN-12-2730.full.pdf

Feb 15, 2013 ... Reagents: G202 (GenSpera); Tasquinimod (Active Biotech ... HDAC4 specific substrate; Bachem Inc.). ... Tris HCl pH 7.4 with 150 mmol/L NaCl/1% Triton and protease ... Isaacs et al. .... 4.8 Æ 0.9% of tumor area in TasQ treated vs. ... untreated control cells. D, TasQ dose-response inhibition of 3D EC.

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Amino acid containing thapsigargin analogues deplete androgen ...

content.stockpr.com

May 5, 2009 ... There are quantitative and/or qualitative mechanisms al- ..... fragmentation into Annexin V–positive apoptotic bodies .... D, XBP-1 processing in LNCaP prostate cancer cells treated with .... J.T. Isaacs and S.R. Denmeade: financial interest, Genspera, Inc., and .... Singh P, Mhaka AM, Christensen SB, et al.

Engineering a Prostate-Specific Membrane Antigen–Activated ...

www.ncbi.nlm.nih.gov

Jun 27, 2012 ... 1, D and E). ..... Purified G202 for animal studies was provided by GenSpera Inc. PSMA ... of Milowsky et al. with a PSMA antibody (clone 3E6; Dako) diluted 1:20 in .... The role of calcium, pH, and cell proliferation in the programmed .... Singh P, Mhaka AM, Christensen SB, Gray JJ, Denmeade SR, Isaacs JT.

Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling ...

cancerres.aacrjournals.org

Feb 15, 2013 ... D, TasQ dose–response inhibition of 3D EC sprouting in fibrin gels over a 7-day ... Reagents: G202 (GenSpera); Tasquinimod (Active Biotech ..... CO2 and decreasing pH, 60% knockdown of HDAC4 decreases survival ..... Denmeade SR,; Mhaka AM,; Rosen DM,; Brennen WN,; Dalrymple S,; Dach I,; et al.