Sep 18, 2014 ... Applicant, Genspera, Inc. ... and (d) reacting the compound of Formula 6 with the
compound of ..... Sci., USA 1996;93:749- 753; Mhaka, A., et al, Cancer Biol Ther.
... by PSMA in vitro and is ~ 60-fold more toxic to PSMA expressing vs. ..... with
1.0 L of 6 M HC1 over 30 minutes (pH~3) a white slurry develops.
Feb 15, 2013 ... D, TasQ dose–response inhibition of 3D EC sprouting in fibrin gels over a 7-day
... Reagents: G202 (GenSpera); Tasquinimod (Active Biotech ..... CO2 and
decreasing pH, 60% knockdown of HDAC4 decreases survival ..... Denmeade
SR,; Mhaka AM,; Rosen DM,; Brennen WN,; Dalrymple S,; Dach I,; et al.
Feb 15, 2013 ... Reagents: G202 (GenSpera); Tasquinimod (Active Biotech ... HDAC4 specific
substrate; Bachem Inc.). ... Tris HCl pH 7.4 with 150 mmol/L NaCl/1% Triton and
protease ... Isaacs et al. .... 4.8 Æ 0.9% of tumor area in TasQ treated vs. ...
untreated control cells. D, TasQ dose-response inhibition of 3D EC.