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Modulating autophagy: a strategy for cancer therapy - NCBI

www.ncbi.nlm.nih.gov/pmc/articles/PMC4012266/

Since Takeshige et al. carried out the first genetic screen for autophagy mutants, ... In the presence of Hsc73 and other Hsp70 co-chaperones, such as Hsp40, Hsp90, ..... Copetti et al. demonstrated that the NF-κB family member p65/RelA (v- rel ... and it is considered the first-line treatment for advanced renal cell carcinoma ...

Treatment outcome of nimotuzumab plus chemotherapy in ... - NCBI

www.ncbi.nlm.nih.gov/pmc/articles/PMC5078104/

Mar 31, 2016 ... In this retrospective study, 205 advanced cancer patients with ... require bivalent binding for stable attachment to the cellular surface, ... Although the co- administered CT regimens were different for ... 53.4%, p=0.004) and GC (72.7% vs. ..... Kim TY, Yamaguchi K, Fuse N, Yamada Y, Ura T, Kim SY, et al.

EGFR inhibitors sensitize non–small cell lung cancer cells to TRAIL ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC4012270/

Non–small cell lung cancer (NSCLC) is the leading cause of death from ... Recent studies have shown that combining cetuximab with first-line chemotherapy improves treatment efficacy in patients with advanced ... and cetuximab (ERBITUX, Merck Co.) ..... Rusch V, Klimstra D, Venkatraman E, et al. .... Park SY, Seol DW.

HSP90 promotes Burkitt lymphoma cell survival by ... - Blood Journal

www.bloodjournal.org/content/early/2016/11/14/blood-2016-06-721423.full.pdf

Nov 15, 2016 ... 14 Department of Medicine V, Heidelberg University Medical Center, ... expression of constitutively active TEL-SYK counteracted the apoptotic effect of .... J et al.5 Protein expression profiling was performed as described previously.5 ..... HSP90 inhibitor, AT13387, in patients with advanced ..... 250 nM PR.

Cell Death and Disease - RBM24 suppresses cancer progression by ...

www.nature.com/cddis/journal/v7/n9/full/cddis2016252a.html

Sep 1, 2016 ... Tel: +862087343191; Fax: +862087343170; E-mail: zengmsh@mail.sysu.edu.cn ... The restoration of RBM24 expression suppressed NPC cellular proliferation, ... results of locoregionally advanced NPC have been disappointing. ... Xie et al. have reported that MALAT1 is significantly upregulated in poorly ...

Cell Death and Disease - The prosurvival protein BAG3: a new ...

www.nature.com/cddis/journal/v7/n10/full/cddis2016321a.html

Oct 20, 2016 ... Correspondence: V De Laurenzi, Department of Biochemical ... 3 (BAG3) protein belongs to the family of co-chaperones that interact with the ... by a more advanced stage of heart failure (HF), suggesting BAG3 protein might ..... Article | PubMed |; Lee MY, Kim SY, Shin SL, Choi YS, Lee JH, Tsujimoto Y et al.

Cell Death and Disease - P300/CBP-associated factor (PCAF ...

www.nature.com/cddis/journal/v7/n10/full/cddis2016247a.html

Oct 6, 2016 ... Tel: +189 9123 2002; Fax: +86 29 8532 3905; E-mail: ... For patients at advanced stage, the efficacy of chemotherapies is unsatisfactory .... (b) Annexin V-FITC/PI labeling showed that forced expression of ..... Article | PubMed | ISI | CAS |; Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J et al.

DNA double-strand break repair: a tale of pathway choices

abbs.oxfordjournals.org/content/48/7/641.full

May 23, 2016 ... Tel: +86-10-68909575; Fax: +86-10-68906307; E-mail: ... DSB repair is critical for genome integrity, cellular homeostasis and also constitutes the ... switching in yeasts [4], V(D)J recombination, and immunoglobulin .... and endonucleolytic activities, which was answered recently by Li et al. ...... Advanced » ...

Inhibition of EGF expression and NF-κB activity by treatment with ...

www.sciencedirect.com/science/article/pii/S1319562X16301681

Nov 21, 2016 ... Effect of quercetin on the rate of cell proliferation was measured by ... the expression level of VEGF (Maeda et al., 1996 and Maeda et al., 1999). ... The cells were cultured in a humidified atmosphere of 5% CO2and .... Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal ...

A phase II study of enzastaurin in combination with erlotinib in ...

www.sciencedirect.com/science/article/pii/S0169500212003844

In previously treated, unselected, advanced NSCLC patients, the addition of .... response (CR) or partial response (PR) (whichever status was recorded first) ... former and current smokers (median PFS of 10.3 vs 1.6 months, respectively; P = 0.02). .... F. Dunphy, The TAX 320 Non-Small Cell Lung Cancer Study Group, et al.