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Titin

en.wikipedia.org/wiki/Titin

Titin /ˈtaɪtɪn/, also known as connectin, is a protein that, in humans, is encoded by the TTN ... The titin protein is located between the myosin thick filament and the Z disk. Titin ...

Titin Structure & Function - Proteopedia, life in 3D

www.proteopedia.org/wiki/index.php/Titin_Structure_&_Function

Jul 11, 2012 ... Titin is a multi-domain structure that which is found to be composed of two ... The protein molecules plays a role in thick-filament and sacromere ...

The role of titin in eccentric muscle contraction | Journal of ...

jeb.biologists.org/content/217/16/2825

Here, I suggest, and provide evidence, that a third filament, titin, is involved in force regulation of sarcomeres by adjusting its stiffness in an activation- dependent ...

The Giant Protein Titin - Circulation Research

circres.ahajournals.org/content/80/2/290.full

The determination of the cDNA sequence of human cardiac titin has shown that the cardiac titin filament is formed by a single, giant, 27 000-residue-long ...

Titin | Chemistry World - Royal Society of Chemistry

www.rsc.org/chemistryworld/2013/10/titin-protein-muscle-podcast

Oct 16, 2013 ... Andrew Holding introduces Titin, the largest protein in the human body. ... It does this by having little 'legs' on the outsides of the filament, which ...

Titin - Faculty of Biological Sciences - University of Leeds

www.fbs.leeds.ac.uk/research/contractility/titin.htm

These have two main functions: In the thick (myosin) filament part of the myofibril we have proposed the titin molecule regulates exact myosin assembly by acting ...

Is titin a 'winding filament'? A new twist on muscle contraction ...

rspb.royalsocietypublishing.org/content/279/1730/981

Sep 7, 2011 ... We propose a 'winding filament' mechanism for titin's role in active muscle. First, we hypothesize that Ca<sup>2+</sup>-dependent binding of titin's N2A ...

The Giant Protein Titin: A Regulatory Node That Integrates Myocyte ...

www.jbc.org/content/286/12/9905.full

Mar 25, 2011 ... The titin filament inserts, with its NH2 terminus, in the Z-disk and reaches all the way to the center of the sarcomere, the M-band (Fig. 1).

Titin: properties and family relationships : Article : Nature Reviews ...

www.nature.com/nrm/journal/v4/n9/full/nrm1198.html

The titin molecule is a flexible filament that is more than 1 mu m long. This spans half the sarcomere, the repeating contractile unit that gives striated muscle its ...

Mutations of TTN, encoding the giant muscle filament titin, cause ...

www.nature.com/ng/journal/v30/n2/full/ng815.html

Jan 14, 2002 ... We show that mutations in the gene encoding giant-muscle filament titin (TTN) cause autosomal dominant DCM linked to chromosome 2q31 ...

More Info

Titin-thin filament interaction and potential role in muscle function.

www.ncbi.nlm.nih.gov

Adv Exp Med Biol. 2000;481:319-33; discussion 334-5. Titin-thin filament interaction and potential role in muscle function. Jin JP(1). Author information:

Roles of Titin in the Structure and Elasticity of the Sarcomere

www.hindawi.com

May 13, 2010 ... The size and structure of the thick filament part of titin is conserved, which is consistent with the conserved structure of thick filaments in ...

Titin

web.stanford.edu

The former two proteins, myosin and actin, form filaments in the sarcomere, while titin is a long linear protein (~1 micron!) made of connected domains like knots ...