Titin /ˈtaɪtɪn/, also known as connectin, is a protein that, in humans, is encoded
by the TTN ... The titin protein is located between the myosin thick filament and
the Z disk. Titin ...
Jul 11, 2012 ... Titin is a multi-domain structure that which is found to be composed of two ... The
protein molecules plays a role in thick-filament and sacromere ...
Here, I suggest, and provide evidence, that a third filament, titin, is involved in
force regulation of sarcomeres by adjusting its stiffness in an activation-
The determination of the cDNA sequence of human cardiac titin has shown that
the cardiac titin filament is formed by a single, giant, 27 000-residue-long ...
Oct 16, 2013 ... Andrew Holding introduces Titin, the largest protein in the human body. ... It does
this by having little 'legs' on the outsides of the filament, which ...
These have two main functions: In the thick (myosin) filament part of the myofibril
we have proposed the titin molecule regulates exact myosin assembly by acting ...
Sep 7, 2011 ... We propose a 'winding filament' mechanism for titin's role in active muscle. First,
we hypothesize that Ca<sup>2+</sup>-dependent binding of titin's N2A ...
Mar 25, 2011 ... The titin filament inserts, with its NH2 terminus, in the Z-disk and reaches all the
way to the center of the sarcomere, the M-band (Fig. 1).
The titin molecule is a flexible filament that is more than 1 mu m long. This spans
half the sarcomere, the repeating contractile unit that gives striated muscle its ...
Jan 14, 2002 ... We show that mutations in the gene encoding giant-muscle filament titin (TTN)
cause autosomal dominant DCM linked to chromosome 2q31 ...