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Titin - Wikipedia

en.wikipedia.org/wiki/Titin

Titin /ˈtaɪtɪn/, also known as connectin, is a protein that, in humans, is encoded by the TTN .... The titin protein is located between the myosin thick filament and the Z disk. Titin...

Titin-thin filament interaction and potential role in muscle function.

www.ncbi.nlm.nih.gov/pubmed/10987081

Titin-thin filament interaction and potential role in muscle function. ... Titin ( connectin) is a giant polypeptide that forms a single-molecule filamental structure  ...

Titin Structure & Function - Proteopedia, life in 3D

www.proteopedia.org/wiki/index.php/Titin_Structure_&_Function

Jul 11, 2012 ... Titin is a multi-domain structure that which is found to be composed of two ... The protein molecules plays a role in thick-filament and sacromere ...

Titin - Faculty of Biological Sciences - University of Leeds

www.fbs.leeds.ac.uk/research/contractility/titin.htm

These have two main functions: In the thick (myosin) filament part of the myofibril we have proposed the titin molecule regulates exact myosin assembly by acting ...

Roles of Titin in the Structure and Elasticity of the Sarcomere

www.hindawi.com/journals/bmri/2010/612482/

May 13, 2010 ... The size and structure of the thick filament part of titin is conserved, which is consistent with the conserved structure of thick filaments in ...

The Giant Protein Titin | Circulation Research

circres.ahajournals.org/content/80/2/290

The determination of the cDNA sequence of human cardiac titin has shown that the cardiac titin filament is formed by a single, giant, 27 000-residue-long ...

A Titan but not Necessarily a Ruler: Assessing the Role of Titin ...

onlinelibrary.wiley.com/doi/10.1002/ar.22987/pdf

that provide motor function, the sarcomere contains titin filaments, com- prised of ... fold for thick filament formation during muscle development, but despite.

Chapter 10 Muscle Tissue Lecture Outline

www2.sunysuffolk.edu/czuraa/BIO130LectureMaterials/BIO130Chapter10Handout.pdf

Titin. Sliding Filament Theory. 1. H-zones and I-bands ↓ width. 2. Zones of overlap ↑ width. 3. Z-lines closer. 4. A-band constant. Events of Muscle Contraction.

Frontiers | Titin isoform size is not correlated with thin filament length ...

journal.frontiersin.org/article/10.3389/fphys.2014.00035/full

Jan 16, 2014 ... The mechanisms controlling thin filament length (TFL) in muscle remain controversial. It was recently reported that TFL was related to titin size, ...

Huxleys' Missing Filament: Form and Function of Titin in Vertebrate ...

www.annualreviews.org/doi/pdf/10.1146/annurev-physiol-022516-034152

Oct 28, 2016 ... connectin, giant sarcomeric proteins, muscle passive tension, titin .... and M-line results in the formation of a titin filament system that is ...

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The role of titin in eccentric muscle contraction | Journal of ...

jeb.biologists.org

Here, I suggest, and provide evidence, that a third filament, titin, is involved in force regulation of sarcomeres by adjusting its stiffness in an activation- dependent ...

Is titin a 'winding filament'? A new twist on muscle contraction ...

rspb.royalsocietypublishing.org

Sep 7, 2011 ... We propose a 'winding filament' mechanism for titin's role in active muscle. First, we hypothesize that Ca<sup>2+</sup>-dependent binding of titin's N2A ...

Titin: properties and family relationships : Article : Nature Reviews ...

www.nature.com

The titin molecule is a flexible filament that is more than 1 mu m long. This spans half the sarcomere, the repeating contractile unit that gives striated muscle its ...