Web Results

Titin

en.wikipedia.org/wiki/Titin

Titin /ˈtaɪtɪn/, also known as connectin, is a protein that, in humans, is encoded by the TTN ... The titin protein is located between the myosin thick filament and the Z disk. Titin ...

The role of titin in eccentric muscle contraction | Journal of ...

jeb.biologists.org/content/217/16/2825

Here, I suggest, and provide evidence, that a third filament, titin, is involved in force regulation of sarcomeres by adjusting its stiffness in an activation- dependent ...

Titin-thin filament interaction and potential role in muscle function.

www.ncbi.nlm.nih.gov/pubmed/10987081

Adv Exp Med Biol. 2000;481:319-33; discussion 334-5. Titin-thin filament interaction and potential role in muscle function. Jin JP(1). Author information:

Titin - Faculty of Biological Sciences - University of Leeds

www.fbs.leeds.ac.uk/research/contractility/titin.htm

These have two main functions: In the thick (myosin) filament part of the myofibril we have proposed the titin molecule regulates exact myosin assembly by acting ...

The Giant Protein Titin - Circulation Research

circres.ahajournals.org/content/80/2/290.full

The determination of the cDNA sequence of human cardiac titin has shown that the cardiac titin filament is formed by a single, giant, 27 000-residue-long ...

Titin

web.stanford.edu/~jenhsin/Titin.html

The former two proteins, myosin and actin, form filaments in the sarcomere, while titin is a long linear protein (~1 micron!) made of connected domains like knots ...

Is titin a 'winding filament'? A new twist on muscle contraction ...

rspb.royalsocietypublishing.org/content/279/1730/981

Sep 7, 2011 ... We propose a 'winding filament' mechanism for titin's role in active muscle. First, we hypothesize that Ca<sup>2+</sup>-dependent binding of titin's N2A ...

The Giant Protein Titin: A Regulatory Node That Integrates Myocyte ...

www.jbc.org/content/286/12/9905.full

Mar 25, 2011 ... The titin filament inserts, with its NH2 terminus, in the Z-disk and reaches all the way to the center of the sarcomere, the M-band (Fig. 1).

Frontiers | Titin isoform size is not correlated with thin filament length ...

journal.frontiersin.org/article/10.3389/fphys.2014.00035/full

The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that ...

Titin Research Roundup

www.uni-muenster.de/Biologie.AllgmZoo/AG-Linke/pages/general/research/research3.htm

Three-filament model of the sarcomere and domain architecture of titin isoforms according to Freiburg et al. (2000). Shown are the structures of human titin ...

More Info

Titin Structure & Function - Proteopedia, life in 3D

www.proteopedia.org

Jul 11, 2012 ... Titin is a multi-domain structure that which is found to be composed of two ... The protein molecules plays a role in thick-filament and sacromere ...

Roles of Titin in the Structure and Elasticity of the Sarcomere

www.hindawi.com

May 13, 2010 ... The size and structure of the thick filament part of titin is conserved, which is consistent with the conserved structure of thick filaments in ...

Titin | Chemistry World - Royal Society of Chemistry

www.rsc.org

Oct 16, 2013 ... Andrew Holding introduces Titin, the largest protein in the human body. ... It does this by having little 'legs' on the outsides of the filament, which ...