Titin /ˈtaɪtɪn/, also known as connectin, is a protein that, in humans, is encoded
by the TTN ... The titin protein is located between the myosin thick filament and
the Z disk. Titin ...
Adv Exp Med Biol. 2000;481:319-33; discussion 334-5. Titin-thin filament
interaction and potential role in muscle function. Jin JP(1). Author information:
Here, I suggest, and provide evidence, that a third filament, titin, is involved in
force regulation of sarcomeres by adjusting its stiffness in an activation-
The determination of the cDNA sequence of human cardiac titin has shown that
the cardiac titin filament is formed by a single, giant, 27 000-residue-long ...
These have two main functions: In the thick (myosin) filament part of the myofibril
we have proposed the titin molecule regulates exact myosin assembly by acting ...
The former two proteins, myosin and actin, form filaments in the sarcomere, while
titin is a long linear protein (~1 micron!) made of connected domains like knots ...
Sep 7, 2011 ... We propose a 'winding filament' mechanism for titin's role in active muscle. First,
we hypothesize that Ca<sup>2+</sup>-dependent binding of titin's N2A ...
Mar 25, 2011 ... The titin filament inserts, with its NH2 terminus, in the Z-disk and reaches all the
way to the center of the sarcomere, the M-band (Fig. 1).
The titin molecule is a flexible filament that is more than 1 mu m long. This spans
half the sarcomere, the repeating contractile unit that gives striated muscle its ...
Jan 14, 2002 ... We show that mutations in the gene encoding giant-muscle filament titin (TTN)
cause autosomal dominant DCM linked to chromosome 2q31 ...