Titin /ˈtaɪtɪn/, also known as connectin, is a protein that, in humans, is encoded
by the TTN ... The titin protein is located between the myosin thick filament and
the Z disk. Titin ...
Here, I suggest, and provide evidence, that a third filament, titin, is involved in
force regulation of sarcomeres by adjusting its stiffness in an activation-
Adv Exp Med Biol. 2000;481:319-33; discussion 334-5. Titin-thin filament
interaction and potential role in muscle function. Jin JP(1). Author information:
These have two main functions: In the thick (myosin) filament part of the myofibril
we have proposed the titin molecule regulates exact myosin assembly by acting ...
The determination of the cDNA sequence of human cardiac titin has shown that
the cardiac titin filament is formed by a single, giant, 27 000-residue-long ...
The former two proteins, myosin and actin, form filaments in the sarcomere, while
titin is a long linear protein (~1 micron!) made of connected domains like knots ...
Sep 7, 2011 ... We propose a 'winding filament' mechanism for titin's role in active muscle. First,
we hypothesize that Ca<sup>2+</sup>-dependent binding of titin's N2A ...
Mar 25, 2011 ... The titin filament inserts, with its NH2 terminus, in the Z-disk and reaches all the
way to the center of the sarcomere, the M-band (Fig. 1).
The mechanisms controlling thin filament length in muscle remain controversial. It
was recently reported that thin filament length was related to titin size, and that ...
Three-filament model of the sarcomere and domain architecture of titin isoforms
according to Freiburg et al. (2000). Shown are the structures of human titin ...