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Novel Data Mining Methodologies for Adverse Drug Event Discovery ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC3675775/

Keywords: Pharmacovigilance, Adverse Drug Events, Data Mining ... Strained by the vast quantities and complexity of data that needed to be examined, ... signal strengthening and signal confirmation follows, where drug safety evaluators look for ..... Then, NLP was used to identify and exclude retrieved articles mentioning ...

Should we stop prescribing metoclopramide as a prokinetic drug in ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC4331179/

Sep 23, 2014 ... In the ICU, off-label prescription of metoclopramide is common. ... The formal EMA statement is as follows: 'In order to minimise the risks of ... In patients on the full feeding regimen there was a nonsignificant trend towards better .... The relevance of tachyphylaxis is still unknown, since combination therapy ...

Marine Drugs | Free Full-Text | BMAA Inhibits Nitrogen Fixation in ...

www.mdpi.com/1660-3397/11/8/3091/htm

Aug 21, 2013 ... Drugs 2013, 11(8), 3091-3108; doi:10.3390/md11083091. Article ... Genome sequencing of toxic bloom-forming cyanobacteria has revealed an ... the uptake of 10 µM <sup>14</sup>C-labelled BMAA, added to actively growing cultures. .... NO3<sup>−</sup> or NH 4<sup>+</sup> did not affect nitrogenase activity to any considerable amount, ...

Publication Bias in Antipsychotic Trials: An Analysis of Efficacy ...

journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001189

Mar 20, 2012 ... FDA Drug Approval Packages for eight second-generation antipsychotics— aripiprazole, ... used to identify a cohort of 24 FDA-registered premarketing trials. .... only to the extent that the available evidence is complete and unbiased. ... The published literature was searched for journal articles matching each ...

Global hazards of herbal remedies: lessons from Aristolochia ...

onlinelibrary.wiley.com/doi/10.15252/embr.201642375/full

First published: 25 April 2016 Full publication history; DOI: 10.15252/embr. 201642375View/save citation; Cited by: 0 articles ... humans began in the early 1990s, when about 100 otherwise healthy Belgian women .... persons and medical professionals to identify the causative actions of a drug taken months or years earlier.

NRDC: Wasted - How America Is Losing Up to 40 Percent of Its Food ...

www.nrdc.org/sites/default/files/wasted-food-IP.pdf

Jonathan Bloom, Author of American Wasteland. Brian Lipinski, World .... amount possible is needlessly squandered on its journey to our plates. This paper ...

Anxiety- and Depression-Like States Lead to Pronounced Olfactory ...

www.jneurosci.org/content/36/2/518.full

Jan 13, 2016 ... Drugs. The dose of CORT and FLX treatments was selected upon ... as follows: open field, elevated plus maze, novelty suppressed feeding, ... anxiety and depression-related behaviors in otherwise naive mice, ... A lentiviral vector was injected in the SVZ at week 8 to label adult ...... Abstract/FREE Full Text.

Stability-mediated epistasis constrains the evolution of an influenza ...

elifesciences.org/content/2/e00631

May 14, 2013 ... Lizhi Ian Gong; Marc A Suchard; Jesse D Bloom ... Article · Figures & data · Metrics · Article info ... stabilizing mutations permitting otherwise inaccessible destabilizing ... It may, therefore, be possible to identify enabling mutations based ...... selected points are labeled with the NP var...

Plea Agreement - US Department of Justice

www.justice.gov/opa/documents/gsk/plea-agreement.pdf

Jun 27, 2012 ... interstate commerce of a misbranded drug, Paxil, in violation of 21 U.S.C. .... Deduct two (2) points for GSK's full cooperation and acceptance of ... a criminal fine in the amount of $956,814,400 to be imposed as follows: ... to the various unknown insurance companies and patients and ..... Sara Miron Bloom.

Altered mechanobiology of Schlemm's canal endothelial cells in ...

www.pnas.org/content/111/38/13876.full.html

Sep 23, 2014 ... Collected Articles ..... (A and B) Fluorescent micrographs of normal SC cells labeled for f-actin ... We also identified three genes that were differentially modulated by ... outflow tract of these drugs in lowering IOP in glaucoma is unknown, but ... profiles defining thickness as full width at half-maximum intensity.

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A high-throughput assay for quantifying appetite and digestive ...

www.ncbi.nlm.nih.gov

Jun 24, 2015 ... Drugs or genetic manipulations that alter food intake or digestion ... by a nutrient homeostatic state (i.e., hunger and satiation) is unknown. ... The amount of DiR′ dye varied for Fig. ... Prior exposure to labeled paramecia and behavioral imaging, ... After correction, each image was segmented as follows.

MicroRNAs accurately identify cancer tissue origin : Article : Nature ...

www.nature.com

Mar 23, 2008 ... The concept of cancer of unknown primary origin comes from the ... we construct an miRNA-based tissue classifier to identify the tissue origin ... 1 is assigned to the 'liver' class, otherwise it continues to node no. ... Full size image (71 KB ) ... and demonstrated that the RNA quantity and quality was similar...

Quantification of neurotoxin BMAA (β-N-methylamino-L-alanine) in ...

www.nature.com

Nov 6, 2014 ... Article | Open ... Using deuterium-labeled internal standard, BMAA was quantified as 0.01–0.90 ... which are eutrophic habitats with blooms of cyanobacteria caused by ... to those seafood in some studies was either small or not specified. ..... the BMAA amount in unknown samples could be calculated (Fig.