Fomepizole or 4-methylpyrazole is indicated for use as an antidote in confirmed
or suspected methanol or ethylene glycol poisoning. It may be used alone or in ...
Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that
catalyzes the initial steps in the metabolism of ethylene glycol and methanol to ...
Fomepizole official prescribing information for healthcare professionals. Includes:
indications, dosage, adverse reactions, pharmacology and more.
May 21, 2009 ... Clinical Therapeutics from The New England Journal of Medicine — Fomepizole
for Ethylene Glycol and Methanol Poisoning.
Feb 8, 2001 ... We performed a multicenter study to evaluate fomepizole, an inhibitor of alcohol
dehydrogenase, in the treatment of patients with methanol ...
Fomepizole is a pyrazole with competitive alcohol dehydrogenase inhibitor
activity. Fomepizole prevents the metabolism of ethylene glycol and methanol by
Mar 11, 2016 ... Dialysis should be considered in addition to fomepizole in the case of renal
failure, significant or worsening metabolic acidosis, or a measured ...
Neth J Med. 2014 Feb;72(2):73-9. Ethylene glycol or methanol intoxication: which
antidote should be used, fomepizole or ethanol? Rietjens SJ(1), de Lange DW ...
Intensive Care Med. 2001 Aug;27(8):1370-8. Treatment of acute methanol
poisoning with fomepizole. Mégarbane B(1), Borron SW, Trout H, Hantson P,
Clin Toxicol (Phila). 2010 Jun;48(5):401-6. doi: 10.3109/15563650.2010.495347.
Fomepizole for the treatment of pediatric ethylene and diethylene glycol, ...