Nitisinone (INN), also known as NTBC is a medication used to slow the effects of
hereditary tyrosinemia type 1. Since its first use for this indication in 1991, it has ...
ORFADIN contains nitisinone, which is a hydroxyphenyl-pyruvate dioxygenase
inhibitor indicated as an adjunct to dietary restriction of tyrosine and ...
nitisinone treatment, a diet deficient in phenylalanine and tyrosine is ... after the
start of nitisinone treatment, the nitisinone dose should be increased to 1.5 mg/kg
Nitisinone or NTBC (2-(2- nitro-4-trifluoromethylbenzoyl)-1 ... nitisinone as a
herbicide was discontinued, ongoing animal studies were halted and not
Apr 26, 2016 ... ORFADIN® (nitisinone) blocks the breakdown of tyrosine, thereby reducing the
amount of toxic by-products in the body. In the most common ...
Metabolism. 2005 Jun;54(6):719-28. Use of nitisinone in patients with
alkaptonuria. Suwannarat P(1), O'Brien K, Perry MB, Sebring N, Bernardini I, ...
Description, Nitisinone is a synthetic reversible inhibitor of 4-
hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary
tyrosinemia type 1.
Sigma-Aldrich offers Sigma-SML0269, Nitisinone for your research needs. Find
product specific information including CAS, MSDS, protocols and references.
Nov 5, 2014 ... Nitisinone works by preventing the body from breaking down an amino acid
called tyrosine and by keeping other toxic substances from building ...
Jan 18, 2002 ... Orfadin® capsules contain nitisinone, which is a synthetic reversible inhibitor of.
4-hydroxyphenylpyruvate dioxygenase used in the treatment of ...