Protamines are small, arginine-rich, nuclear proteins that replace histones late in
the haploid phase of spermatogenesis and are believed essential for sperm ...
Medscape - Indication-specific dosing for (protamine), frequency-based adverse
effects, comprehensive interactions, contraindications, pregnancy & lactation ...
Nov 21, 2008 ... Protamine Sulfate Injection, USP is a sterile, non-pyrogenic, isotonic solution of
protamine sulfate in Water for Injection. It acts as a heparin ...
Nov 21, 2008 ... Learn about indications, dosage and how it is supplied for the drug Protamine (
Protamine Sulfate Injection official prescribing information for healthcare
professionals. Includes: indications, dosage, adverse reactions, pharmacology
Protamine Sulfate reference guide for safe and effective use from the American
Society of Health-System Pharmacists (AHFS DI).
Fish allergy. Previous exposure to protamine (including insulin). Severe left
ventricular dysfunction. Abnormal pulmonary hemodynamics. Previous
strongly basic protamine + strongly acid heparin -> forms stable salt -> removed
by reticuloendothelial system. inhibits formation and activity of thromboplastin ...
The administration of protamine has been associated with different side effects
such as anaphylactic reaction, hypotension, and pulmonary hypertension ...
Protamine reversal of low molecular weight heparin: clinically effective? van
Veen JJ(1), Maclean RM, Hampton KK, Laidlaw S, Kitchen S, Toth P, Makris M.