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Tenecteplase

en.wikipedia.org/wiki/Tenecteplase

Tenecteplase (INN) (trade name TNKase) is an enzyme used as a thrombolytic drug. Tenecteplase is a tissue plasminogen activator (tPA) produced by ...

TNKase® Acute Myocardial Infarction Treatment

www.tnkase.com/

Learn more about single-bolus TNKase® (tenecteplase) acute myocardial infarction treatment and the 5-second TNKase® dosing and administration. Indication ...

Tnkase (Tenecteplase) Drug Information: Indications, Dosage and ...

www.rxlist.com/tnkase-drug/indications-dosage.htm

Learn about indications, dosage and how it is supplied for the drug Tnkase ( Tenecteplase).

TNKase® (Tenecteplase) DESCRIPTION TNKase® (Tenecteplase ...

www.gene.com/download/pdf/tnkase_prescribing.pdf

TNKase® (Tenecteplase) is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line ( Chinese ...

Tenecteplase (TNK-tPA) - LITFL: Life in the Fast Lane Medical Blog

lifeinthefastlane.com/ccc/tenecteplase-tnk-tpa/

CLASS. thrombolytic. MECHANISM OF ACTION. selectively binds to fibrin and converts plasminogen -> plasmin -> degradation of fibrin matrix.

Review of tenecteplase (TNKase) in the treatment of acute ... - NCBI

www.ncbi.nlm.nih.gov/pmc/articles/PMC2672445/

Apr 8, 2009 ... TNKase is a genetically engineered variant of the alteplase molecule. Three different mutations result in an increase of the plasma half-life, ...

DrugBank: Tenecteplase

www.drugbank.ca/drugs/DB00031

Jun 13, 2005 ... Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for ...

Label - Tenecteplase (TNKase), Genetech, Inc. - FDA

www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/TherapeuticBiologicApplications/UCM200875.pdf

Tenecteplase is a tissue plasminogen activator (tPA) produced by ... Each vial of TNKase nominally contains 52.5 mg Tenecteplase, 0.55 g L-Arginine, 0.17 g.

Pharmacotherapy Update | Tenecteplase (TNKase): A Clinical Review

www.clevelandclinicmeded.com/medicalpubs/pharmacy/JanFeb2001/tenecteplase.htm

Tenecteplase has an initial half-life of 20 to 24 minutes with a terminal half-life of 90 to 130 minutes with a mean plasma clearance ranging from 99 to 119 ...

A Randomized Trial of Tenecteplase versus Alteplase for Acute ...

www.nejm.org/doi/full/10.1056/NEJMoa1109842

Mar 22, 2012 ... Tenecteplase was associated with significantly better reperfusion and clinical outcomes than alteplase in patients with stroke who were ...

More Info

Tenecteplase medical facts from Drugs.com

www.drugs.com

Physician reviewed tenecteplase patient information - includes tenecteplase description, dosage and directions.

TNK tPA, TNKase (tenecteplase) dosing, indications, interactions ...

reference.medscape.com

Medscape - Indication-specific dosing for TNK tPA, TNKase (tenecteplase), frequency-based adverse effects, comprehensive interactions, contraindications,  ...

Genentech: TNKase® (tenecteplase) - Information for Patients

www.gene.com

TNKase<sup>®</sup> (Tenecteplase) is a single-bolus thrombolytic, or clot-busting agent, approved by the U.S. Food and Drug Administration for use in mortality reduction  ...