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Antibody humanization by molecular dynamics simulations—in ...


Jan 8, 2016 ... Further advanced protocols include resurfacing (Roguska et al., 1994), ... critical human anti-mouse (Schroff et al., 1985; Shawler et al., 1985; Sgro, ... the overall protein structure or the VH/VL interface (Chothia et al., 1989), ...

Phase II Study of Belagenpumatucel-L, a Transforming Growth ...


Oct 10, 2006 ... Terry Chamberlin, Daniel L. Shawler, and Habib Fakhrai. A. B. S. T. R. A. C ...... Melloni G, Ferreri AJ, Russo V, et al: Prognos- tic significance of ...

The Koziol Laboratory - The Scripps Research Institute


Wagner, S., Tagaya, M., Koziol, J.A., Quaranta, V. and Del Zoppo, G.J. Rapid disruption of an astrocyte interaction ... Sobol, R.E., Fakhrai, H., Shawler, D. et al.

English (pdf) - SciELO


cal settings (Reichert et. al., 2005; Waldmann, 2003). Indeed ... et al., 1985; Shawler et al., 1985). ... for genes encoding the variable regions (V) and constant .

Post-Fall Decision Making Among Older Women Living in ...


Dec 14, 2015 ... v. ABSTRACT. Introduction: One in every three adults over the age of 65 ..... year in direct medical costs (Stevens, et al., 2006). ..... support, assistance, and advice in the decision making (Shawler, et al., 2001; Waldron,.

What can virtual patient stimulation offer mental health nurse ...


V. Guise. Faculty of Health and Social Care. Sciences. St George's University of London .... (SPs) and environments (Shawler 2008, Zavertnik et al. 2010); and ...

Antibodies against Alpha-Synuclein Reduce Oligomerization in ...


Oct 31, 2011 ... ... Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, et al. .... α-synuclein oligomers [11] diluted 1∶1 (v:v) with Freund's adjuvant. ..... Hagan PL, Halpern SE, Dillman RO, Shawler DL, Johnson DE, et al.

Download as a PDF - CiteSeerX


Jun 1, 2000 ... [Reviewed in this issue by Little et al]. In turn, these ... But was this the right way to go for antibody variable (V-) regions, or is it a case ..... 4 Shawler, D.L. et al (1985 ) Human immune responses to multiple injections of murine.

Dose escalation and pharmacokinetic study of a ... - Europe PMC


murine mabs (Schroff et al, 1985; Shawler et al, 1985). Carter and .... curve ( AUC0–∞), distribution volume (V) and serum clearance (CL) were estimated.

Monoclonal Antibody Development and Physicochemical ... - InTech


Feb 17, 2012 ... Gagnon, 2004; DiMasi et al., 2003) and over $1 billion to bring a new biologic ... 2007; Kuus-Reichel et al., 1994; Shawler et al., 1985). ...... equipment composition (e.g. stainless steel vs. titanium) is one of the factors to be.

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Treatment of Steroid-Resistant Acute Graft-vs-host Disease by In ...


Jun 3, 1988 ... Doney KC, Weiden PL, Storb R, et al: Treatment of graft-versus-host disease in ... Dillman RO, Shawler DL, Dillman JB, et al: Therapy of chronic ...

CD24+/CD38- as new prognostic marker for non-small cell lung ...


Karimi-Busheri et al.; licensee BioMed Central Ltd. 2013 ..... Karimi-Busheri F, Zadorozhny V, Li T, Lin H, Shawler DL, Fakhrai H: Pivotal role of CD38 biomarker  ...

Immune-Modulating Vaccines in Non-small Cell Lung Cancer


Nov 20, 2015 ... Overall survival for cohorts 1 versus 2 and 3 for patients with ... Lu et al. used a model of urethane-induced lung tumors in A/J mice that harbor Ras codon .... 31; O Dorigo, DL Shawler, I Royston, RE Sobol, JS Berek, H Fakhrai.