Trypsinogen (EC 126.96.36.199/20/21/23/24/26) is the precursor form or zymogen of
trypsin, a digestive ...
The premature activation of trypsinogen in the pancreatic interstitium, with the
subsequent activation of other pancreatic zymogens, is believed to lead to the ...
Pancreatic zymogens are normally only activated after they reach the small
intestine. A brush border enzyme, enterokinase, cleaves a peptide from
the inactive precursor of trypsin, secreted by the pancreas and activated to trypsin
by contact with enterokinase. Miller-Keane Encyclopedia and Dictionary of ...
Trypsin and Chymotrypsin. Pancreatitis, when control fails. Any disturbance of the
balance between proteolytic enzymes and their inhibitors, or of the activation ...
The two proteases trypsin and chymotrypsin are grouped into the serine protease
... are used as the major form of control once the protease has been activated.
The past three decades have seen the development of several animal models of
pancreatitis and remarkably, early intracellular trypsinogen activation has been ...
Trypsinogen and chymotrypsinogen, zymogens secreted by the pancreas, are
activated in the intestinal tract to trypsin and chymotrypsin. Activation is effected
May 4, 2015 ... Trypsin then activates the precursors of chymotrypsin, elastase, and
carboxypeptidase. When the pancreatic enzymes become activated in the ...
Activation of trypsin is now believed to represent the linchpin of acute pancreatitis
, and, indeed, trypsin is activated within pancreatic acinar cells early in the ...