A gene knockout (abbreviation: KO) is a genetic technique in which one of an
organism's genes is made inoperative Also known as knockout organisms or ...
Sep 4, 2013 ... Short animation explaining the basics of one step gene knockout. This is the most
widely used method to make knockout.
The most common application of gene targeting is to produce knockout mice,
where a drug resistance marker replaces an essential coding region in a genetic
This is because knocking out a gene (as it is called) is important in so much of
biology. For example, if you type "knockout mouse" into PubMed (a search
Nov 17, 2014 ... describing the principles of gene knockout and its application.
Most commonly, the Cre-lox system  is utilized for conditional mutation of a
gene. Using a conditional knockout approach limits the risk of embryonic lethality
copies of the mutated gene. These are what we commonly call “knockout mice”,
and these are the ones we. are most interested in studying. HOMOZYGOUS ...
However, because so many mouse genes are similar to human genes,
geneticists can generate knockout mice in which the mouse counterpart of a
human gene ...
There are at least thousands of genes in the DNA of most organisms, and more
than 20,000 in the DNA of each human being, for instance. How can we ...
Permanent change in DNA leading to the loss of function of a gene, caused by a
manipulation of the organism's DNA in a laboratory followed by breeding to ...