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en.wikipedia.org/wiki/Proenkephalin

Proenkephalin (PENK), formerly known as proenkephalin A is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides [Met]enkephalin, and to a lesser extent, [Leu]enkephalin. Upon cleavage, each proenkephalin peptide results in the generation of four copies of ...

www.nature.com/articles/ncomms9967

Dec 4, 2015 ... Here we report that Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and ..... Waxman , S. G. et al. Sodium channel genes in pain-related disorders: phenotype- genotype associations and recommendations for clinical use . Lancet ...

jalm.aaccjnls.org/content/jalm/early/2017/09/29/jalm.2017.023598.full.pdf

Sep 29, 2017 ... Page 2 ..... Kim et al. (2017). Sepsis. (167). PENK vs. NGAL in detecting. AKI. ( diagnosed with. KDIGO), compared with. eGFRs. (MDRD and. CKD-EPI. Cr. / CystC. /Cr-CystC). AUC: PENK. 0.725,. NGAL. 0.675, not statistically different. Nested logistic regression: PENK superior to. NGAL. (P. = 0.022),. PENK.

www.onlinejacc.org/content/accj/69/1/56.full.pdf

Jan 3, 2010 ... Page 1 ... CONCLUSIONS PENK levels reflect cardiorenal status in acute HF and are prognostic for worsening renal function and in-hospital ... strated that opiate administration in acute HF has been associated with poor outcomes (7). Fontana et al. (8) reported elevated met-enkephalin levels in severe.

onlinelibrary.wiley.com/doi/pdf/10.1111/gbb.12139

effects (Baamonde et al. 1992; Broom et al. 2002;. Tejedor-Real et al. 1995, 1998 ). In addition, mice deficient in enkephalin preproenkephalin knockout (PENK ..... vs. PENK KO CMS: P < 0.001). Corticosterone levels were higher in PENK KO mice under baseline conditions but lower after CMS compared with those in WT ...

onlinelibrary.wiley.com/doi/10.1111/2041-210X.12817/full

Jun 26, 2017 ... Observed trophic interactions in a given environment may not fully represent the feeding preferences of an organism (Devictor et al., 2010; Futuyma ... such as altered diversity, structure and functioning of target communities (Jackson et al., 2016; Lockwood, Hoopes, & Marchetti, 2007; Penk et al., 2015).

www.tandfonline.com/doi/pdf/10.1080/17445647.2014.921647

cators for a once-extensive European ice shield, Penck and Brückner (1909) reconstructed ice ages from moraines and ... Wright, 1976; Boulton & Clark, 1990 ), digital terrain models (e.g. Berthier et al., 2007; Mohr,. Reeh ... based on the conventional wisdom of V-shaped fluvial and U-shaped glacial valley cross sections.

www.jbc.org/content/early/2010/03/26/jbc.M110.103283.full.pdf

Mar 26, 2010 ... Richard M. Page, Amelie Gutsmiedl, Akio Fukumori, Edith Winkler, Christian Haass & ..... lowered. As shown in Fig. 1C, all GSMs were effective. GSM-1, a previously described GSM which is effective in the low-micromolar range (24,28), was overall the most ..... cultured cells versus the cell-free system,.

www.cdc.gov/vaccines/pubs/pinkbook/index.html

Dec 30, 2016 ... Printer friendly version[12 pages](https://www.cdc.gov/vaccines/pubs/pinkbook/ downloads/table-of-contents.pdf). The 13th Edition Epidemiology and Prevention of Vaccine-Preventable Diseases, a.k.a. the “Pink Book,” provides physicians, nurses, nurse practitioners, physician assistants, pharmacists, and ...