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en.wikipedia.org/wiki/Effect_of_spaceflight_on_the_human_body

Other significant effects include a slowing of cardiovascular system functions, decreased production of red blood cells, balance disorders, eyesight disorders and a weakening of the immune system. Additional symptoms include fluid redistribution (causing the "moon-face" appearance typical in pictures of astronauts ...

www.nasa.gov/mission_pages/station/research/news/functional_immune

Apr 5, 2017 ... European Space Agency astronaut Andre Kuiper, shown here in the Human Research Facility, prepares samples for the Integrated Immune study. ... are working to define, and perhaps develop mitigations for, immune issues before embarking on deep space missions, where the immune system will be ...

www.nasa.gov/content/study-reveals-immune-system-is-dazed-and-confused-during-spaceflight-u

Aug 18, 2014 ... European Space Agency astronaut Andre Kuipers, Expedition 30 flight engineer, prepares vials in the Columbus laboratory of the International Space Station for venous blood sample draws during an immune system investigation. Credits: NASA. Data generated early in NASA's Integrated Immune study ...

www.space.com/26903-astronaut-immune-systems-in-space.html

Aug 22, 2014 ... New research led by NASA shows that spaceflight confuses the immune system.

io9.gizmodo.com/why-do-our-immune-systems-falter-in-space-1668217291

Dec 8, 2014 ... The exact mechanism behind why our immune systems become less effective in space isn't completely understood yet. ... some of the changes are due to the effects of microgravity which has been seen to have at least some short-term (and happily reversible) impacts to how well immune systems work.

science.time.com/2012/10/22/dont-sneeze-in-space-when-astronauts-get-sick

Oct 22, 2012 ... Mermel began his work by surveying the health records of astronauts across the 30 year history of the space shuttle program, and the results were troubling. ... For reasons scientists have not quite figured out, the immune system can go on the fritz in space: wounds heal more slowly; infection-fighting T-cells ...

www.signaltonoisemag.com/allarticles/2016/11/14/sick-in-space-stress-compromises-astronauts-immune-systems

Nov 14, 2016 ... Stress hormones alter the circulation of phagocytes and, in both intense exercisers and short-flight astronauts, actually increase phagocyte levels and thus improve defenses against infection. But long-flight astronauts don't get the same boost; in fact, it's the opposite [2]. The stressors of long-term space ...

www.popsci.com/science/article/2009-11/mutant-bacteria-are-likely-threaten-future-space-travelers

Nov 5, 2009 ... To top it off, bacteria are more virulent and antibiotics don't work as well in space, so higher concentrations are needed to thwart infection. "Even after we figure out a way to ... NASA has known since Apollo that astronauts' immune systems don't function well in space. Take the body's first line of defense, ...

www.esa.int/Our_Activities/Human_Spaceflight/Research/Finding_the_key_to_immunity

Feb 4, 2013 ... Living in space weakens astronauts' immune systems, researchers have discovered. ... By comparing the samples, investigators saw what was stopping the immune cells from working properly. A specific transmitter in the immune cells , called the Rel/NF-κB pathway, stops working in weightlessness.