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Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system. Antithrombin is a glycoprotein produced by the liver and consists of 432 amino acids. It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin ...


Antithrombin (AT, Antithrombin III, ATIII) is a small glycoprotein produced by the liver that inactivates several enzymes of the coagulation system. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites. A single glycosylation site ...


Feb 28, 2017 ... Antithrombin III (ATIII) is a nonvitamin K-dependent protease that inhibits coagulation by lysing thrombin and factor Xa. Antithrombin III activity is markedly potentiated by heparin, the principle mechanism by which both heparin and low molecular weight heparin result in anticoagulation.


Apr 29, 2016 ... Antithrombin testing is primarily ordered, along with other tests for excessive clotting disorders, to investigate the cause of recurrent blood clot formation ( thrombosis). Testing evaluates the activity (function) and the amount (quantity) of antithrombin and helps identify antithrombin deficiency. (For more about ...


Jul 25, 2017 ... Deficiency of antithrombin (AT; antithrombin III) can be inherited or acquired. In some patients, AT deficiency can be associated with an increased risk of thromboembolism. The availability of plasma-derived AT concentrates and recombinant AT has mad.


Antithrombin Deficiency Resources. A Genetic or Acquired Clotting Condition or Thrombophilia. If you have Antithrombin Deficiency (AT), you were either born with it and it is an inherited or genetic clotting disorder, or you acquired it. If you have the genetic or inherited form, you are at an increased risk of getting a blood clot.


Antithrombin inactivates factor Xa (activated factor X) and activated factor II ( thrombin). Therefore, activity is increased by heparin. In surgeries in which cardiopulmonary bypass is used and heparin is the anticoagulant employed, measuring antithrombin III (ATIII) levels prior to surgery may be useful. Individuals with low ATIII ...


People with antithrombin deficiency are at risk of developing a blood clot ( thrombus) within a vein (thrombosis). The first episode of thrombosis typically occurs before the age of 40 years. A thrombus is a clump of blood cells (i.e., platelets, clotting factors, fibrin, etc.) that may become attached (adhere) to the interior wall of a ...


May 20, 2016 ... Read our article and learn more on MedlinePlus: Antithrombin III blood test.