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Astemizole was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It has been withdrawn from the market in most countries because of rare but potentially fatal side effects (QTc interval prolongation and related arrhythmias due to hERG  ...


Learn about Hismanal (Astemizole (WITHDRAWN FROM US MARKET)) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.


Jun 13, 2005 ... Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.


Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long -acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, ...


Physician reviewed astemizole patient information - includes astemizole description, dosage and directions.


In prospective studies on astemizole use in 187 pregnancies, no association was found between astemizole exposure in the first trimester and the occurrence of congenital malformations or other adverse effects (Diav-Citrin 2003, Pastuszak 1998). However, like terfenadine, astemizole has been withdrawn in many ...


Find patient medical information for Astemizole Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.


Astemizole was first marketed in the UK in 1983 and approved by the FDA in the USA in 1988. However, Johnson & Johnson voluntarily withdrew astemizole from the global market in 1999. The causative adverse events that led to withdrawal maybe related to slow potassium channels in the heart and result in torsade de ...


astemizole (Hismanal) is a discontinued allergy drug. Astemizole was removed from the market due to concerns about serious rhythm disturbances.