Jul 2, 2006 ... The allergy medication astemizole could have another life as a potential treatment for malaria, according to a study conducted by researchers from the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins University School of Medicine. The study, largely funded by the Johns Hopkins ...
Slide 7 of 11.
Product Literature References. Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy: D.M. Richards, et al.; Drugs 28, 38 (1984), Abstract;. In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole: P.M. Laduron, et al.; Mol. Pharmacol. 21, 294 (1982) ...
Oct 15, 2012 ... Synopsis: Astemizole1 is an H1-histamine receptor antagonist with a long duration of action permitting once daily administration. Its efficacy in seasonal and perennial allergic rhinitis has been convincingly demonstrated, and several comparative studies suggest that astemizole is at least as effective as ...
The pharmacokinetics of a single oral dose of 3H-astemizole (AST) of 1 mg/kg was studied in Beagle dogs and compared with that of a tracer dose superposed at the end of a subchronic experiment. Single and superposed doses were equally well absorbed, and elimination half-lives of AST and of its metabolites were ...
ABSTRACT: Astemizole is a long-acting, highly selective. histamineI-receptor antagonist with minimal central and anticholinergic effects. Comparison studies have shown astemizole to be equal or superior to currently available antihistamines, beclomethasone nasal spray, and cromolyn sodium in relieving.
HISMANAL®. Johnson & Johnson Merck. Astemizole. Histamine H1-Antagonist. Action And Clinical Pharmacology: Astemizole is a potent, long-acting, and selective histamine H1-antagonist. It produces a dose-related inhibition of skin reactions to intradermal histamine. Astemizole inhibits the nose reaction to nasal ...
ASTEMIZOLE USE WITH. ERYTHROMYCIN. To the Editor: I noted the study of Delgado et al that was recently published in the Annals concerning safety of second generation antihistamines in atopic children.1 In this study, Janssen Pharmaceutica's product, Hismanal (astemizole) was prescribed concomitantly with erythro-.
A Short Synthesis of Astemizole. References · Citations; Metrics; Reprints & Permissions · PDF. Abstract. The synthesis of astemizole 6, a potent H1- antihistaminic agent, was achieved in 20% overall yield. Compound 6 was obtained in high purity and on a multigram scale starting from 2- hydroxybenzimidazole.