Web Results

pubs.acs.org/doi/abs/10.1021/jm501230c

Nov 4, 2014 ... In the present study, we identified astemizole, an FDA-approved drug, as a small molecule inhibitor of the EZH2-EED interaction of PRC2.

www.chemspider.com/Chemical-Structure.2160.html

Structure, properties, spectra, suppliers and links for: Astemizole.

www.jacionline.org/article/S0091-6749(96)70122-7/abstract

Since the introduction of nonsedating selective H1 antagonists, they have been largely used by women of reproductive age for the treatment of seasonal allergic  ...

www.tandfonline.com/doi/abs/10.1080/00397919608004642

The synthesis of astemizole 6, a potent H1-antihistaminic agent, was achieved in 20% overall yield. Compound 6 was obtained in high purity and on a multigram ...

www.prionalliance.org/2013/05/07/no-effective-therapy-yet-but-lots-to-be-optimistic-about

May 7, 2013 ... Above: The new studies on astemizole and anle138b both relied on high- throughput screening using tools like these 96-well plates to test ...

www.pnas.org/content/110/17/7044

Apr 23, 2013 ... We screened a collection of drugs approved for human use and identified astemizole and tacrolimus, which reduced cell-surface PrP and ...

onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.430080106

The excretion and biotransformation of astemizole (AST) were studied after single admin- istration in rats (0.16 or 10 mglkg), guinea-pigs (0.16 mglkg), dogs ( 1 ...

www.cureffi.org/2013/04/04/tacrolimus-astemizole-and-a-new-screening-approach-for-drugs-that-reduce-prp

Apr 4, 2013 ... A few hours ago someone left me a comment (thanks!) pointing me to a new prion therapeutic study hot off the press in PNAS from the folks at ...

www.druglib.com/activeingredient/astemizole

Astemizole, an H1-receptor antagonist, is similar in structure to terfenadine and haloperidol, a butyrophenone antipsychotic. It has anticholinergic (atropine-like)  ...