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en.wikipedia.org/wiki/Leukocyte_adhesion_deficiency

Leukocyte adhesion deficiency (LAD), is a rare autosomal recessive disorder characterized by immunodeficiency resulting in recurrent infections. LAD is currently divided into three subtypes: LAD1, LAD2, and the recently described LAD3, also known as LAD-1/variant. In LAD3, the immune defects are supplemented by a ...

emedicine.medscape.com/article/887236-overview

Oct 19, 2016 ... Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection.

ghr.nlm.nih.gov/condition/leukocyte-adhesion-deficiency-type-1

2 days ago ... Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Immunodeficiencies are conditions in which the immune system is not able to protect the body effectively from foreign invaders such as viruses, bacteria, and fungi.

rarediseases.org/rare-diseases/leukocyte-adhesion-deficiency-syndromes

The absence of pus formation at the site of infection is an important feature that can indicate a leukocyte adhesion deficiency. Delayed detachment of the umbilical cord often occurs along with infection of the umbilical cord stump ( omphalitis). Recurrent, bacterial infections usually develop shortly after birth in LAD I and can ...

www.uptodate.com/contents/leukocyte-adhesion-deficiency

Mar 28, 2017 ... Defects in a number of these adhesion molecules result in recognized clinical syndromes. Three leukocyte-adhesion deficiency (LAD) syndromes have been delineated, and a fourth category of other neutrophil adhesion defects has been proposed [1]:. ○LAD I, in which the beta-2 integrin family is deficient ...

www.merckmanuals.com/professional/immunology-allergic-disorders/immunodeficiency-disorders/leukocyte-adhesion-deficiency

Leukocyte Adhesion Deficiency. By James Fernandez, MD, PhD, Clinical Assistant Professor of Medicine;Director, Allergy and Clinical Immunology; Cleveland Clinic, Staff, Department of Allergy and Clinical Immunology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University ;Louis Stokes VA ...

www.merckmanuals.com/home/immune-disorders/immunodeficiency-disorders/leukocyte-adhesion-deficiency

Leukocyte Adhesion Deficiency. By James Fernandez, MD, PhD, Clinical Assistant Professor of Medicine;Director, Allergy and Clinical Immunology; Cleveland Clinic, Staff, Department of Allergy and Clinical Immunology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University ;Louis Stokes VA ...

www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=99843

Leukocyte adhesion deficiency type II. Disease definition. Leukocyte adhesion deficiency type II (LAD-II) is a form of LAD (see this term) characterized by recurrent bacterial infections, severe growth delay and severe intellectual deficit.

www.sciencedirect.com/science/article/pii/S092544399900071X

Leukocyte adhesion deficiency type II (LAD II) is a rare disorder characterized by recurrent infections, persistent leukocytosis, and severe mental and growth retardation. LAD II neutrophils are deficient in expression of selectin ligand activity, and exhibit a correspondingly diminished ability to roll on endothelium and to traffic ...